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KMID : 0377619640070060757
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Korean Jungang Medical Journal
1964 Volume.7 No. 6 p.757 ~ p.764
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Clinical Observations on the Chemotherapy of Crebral Paragonimiasis with Bithionol
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金輔星/Sim, Bo Sung
朱正和/朱東善/尹金重/崔吉洙/徐浚根/Chu, Jeong Wha/Chu, Dong Sun/Yoon, Kum Chun/Choi, Kil Soo/Suh, Jun Kun
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Abstract
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So far various drugs have been tried for the treatment of pulmonary paragonimiasis without any appreciable effect. Since the first report of Yokogawa on an excellent result of Bithionol for the treatment of pulmonary paragonimiasis in 1960 many reports have been published with same excellent results.
However, there has been no trial of this drug for the treatment of cerebral parago nimiasis.
This study is intended to investigate the effect of Bithionol on the cerebral paragonimiasis.
Bithionol is given to 18 patients with cerebral paragonimiasis in a dose of 4050 mg/kg body weight per day, every other day for one month.
Daily dose was divided into three and given post-prandially.
Following results are obtained:
① In no case, the negative conversion of the eggs per day (E.P.D.) occured in the first ten days after initiation of therapy, in 58% of cases in the second ten days, in 33 % in the last ten days.
In one case, the negative conversion was observed at the 31st day of treatment.
In a series of patients in whose stool egg of paragonimus was found, the negative conversion of E.P.G. occurred in 75% in the second ten days and 25% in the last ten days.
② In six cases with meningitis symptoms, meningeal symptom have cleared up within the first ten days which had been also proved by the spinal. fluid findings.
③ Major symptoms of pulmonary paragonimiasis such as bloody sputum, fish oder, sputum, and hemoptysis had disappeared in 55% of cases in the first ten days, in 31% in the second ten days, and 14% in the last ten days.
④ Side effects of Bithionol had occured as follows; diarrhea in 25. 8% of cases, dizziness in 12.6%o anorexia in 9.9%, abdominal pain in 12. 6% indigeston in 9. 9%, mild fever in 6. 4%, generalized muscular pain in 3. 2%, erythema in 9. 9% eruption in 6. 4%, and itching in 3. 2%.
⑤ Meningeal irritation signs such as headache, stiffneck and vomiting had disappeared in the first 20 days after treatment in all cases except for 3 cases in which headaehe has persist until the end of one course.
⑥ Improvement of focal symptoms or convulsions typical for the chronic form of cerebral paragonimiasis was not so appreciable, but aggrevation of symptoms is not observed in any of our cases.
⑦ From these, it can be concluded that Bithional is effective for the treatment of cerebral paragonimiasis, especially in the acute forms of cerebral paragonimiasis.
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